Amanda Seyfried first broke out in 2004 as the hilarious, ditzy Karen in Mean Girls. Since then, she’s gone on to become one of the defining actors of her generation, starring in everything from Mamma Mia! to 2020’s Mank, which earned her an Academy Award nomination. 2025 was one of her biggest years to date, with leading roles in both The Housemaid, a major box office hit, and the critically acclaimed The Testament of Ann Lee.